Palmitoyl-KVK-L-ascorbic acid conjugate improves matrix abnormality associated with skin aging via epigenetic regulation

Min-Kyoung Kim; Mi Hee Shin; Joo Hyuck Lim; Jung Soo Bae; Yu Ri Lee; Hye Sun Shin; Soo Ick Cho; Jin Ho Chung; Dong Hun Lee

doi:10.1016/j.jdermsci.2020.12.006

Palmitoyl-KVK-L-ascorbic acid conjugate improves matrix abnormality associated with skin aging via epigenetic regulation

J Dermatol Sci. 2021 Mar;101(3):214-217. doi: 10.1016/j.jdermsci.2020.12.006. Epub 2021 Jan 4.

Authors

Min-Kyoung Kim¹, Mi Hee Shin², Joo Hyuck Lim³, Jung Soo Bae³, Yu Ri Lee⁴, Hye Sun Shin⁴, Soo Ick Cho¹, Jin Ho Chung⁵, Dong Hun Lee⁶

Affiliations

¹ Department of Dermatology, Seoul National University College of Medicine, Seoul, Republic of Korea; Laboratory of Cutaneous Aging Research, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea; Institute of Human-Environment Interface Biology, Seoul National University, Seoul,Republic of Korea.
² Department of Dermatology, Seoul National University College of Medicine, Seoul, Republic of Korea; Laboratory of Cutaneous Aging Research, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea; Institute of Human-Environment Interface Biology, Seoul National University, Seoul, Republic of Korea.
³ Biotechnology Research Institute, R&D Division, Celltrion, Inc., Incheon, Republic of Korea.
⁴ Department of Dermatology, Seoul National University College of Medicine, Seoul, Republic of Korea; Laboratory of Cutaneous Aging Research, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea; Institute of Human-Environment Interface Biology, Seoul National University, Seoul,Republic of Korea; Department of Biomedical Sciences, Seoul National University Graduate School, Seoul, Republic of Korea.
⁵ Department of Dermatology, Seoul National University College of Medicine, Seoul, Republic of Korea; Laboratory of Cutaneous Aging Research, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea; Institute of Human-Environment Interface Biology, Seoul National University, Seoul,Republic of Korea; Department of Biomedical Sciences, Seoul National University Graduate School, Seoul, Republic of Korea; Institute on Aging, Seoul National University, Seoul, Republic of Korea.
⁶ Department of Dermatology, Seoul National University College of Medicine, Seoul, Republic of Korea; Laboratory of Cutaneous Aging Research, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea; Institute of Human-Environment Interface Biology, Seoul National University, Seoul, Republic of Korea. Electronic address: ivymed27@snu.ac.kr.

PMID: 33431305
DOI: 10.1016/j.jdermsci.2020.12.006

No abstract available

Keywords: DNA methyltransferase 1; Extracellular matrix; Palmitoyl-KVK-L-ascorbic acid; Skin aging; Ultraviolet.

Publication types

Letter

MeSH terms

Antioxidants / administration & dosage*
Antioxidants / chemistry
Ascorbic Acid / administration & dosage*
Ascorbic Acid / chemistry
DNA (Cytosine-5-)-Methyltransferase 1 / antagonists & inhibitors
DNA (Cytosine-5-)-Methyltransferase 1 / metabolism
DNA Methylation / drug effects
Enzyme Assays
Epigenesis, Genetic / drug effects*
Extracellular Matrix / drug effects
Extracellular Matrix / metabolism
Fibroblasts
HEK293 Cells
Humans
Oligopeptides / administration & dosage*
Oligopeptides / chemistry
Skin / cytology
Skin / drug effects
Skin Aging / drug effects*
Skin Aging / genetics

Substances

Antioxidants
Oligopeptides
DNA (Cytosine-5-)-Methyltransferase 1
DNMT1 protein, human
Ascorbic Acid