The cross-talk between signaling pathways, noncoding RNAs and DNA damage response: Emerging players in cancer progression

Faezeh Malakoti; Forough Alemi; Simin Younesi; Maryam Majidinia; Bahman Yousefi; Pejman Morovat; Nafiseh Khelghati; Masoomeh Maleki; Ansar Karimian; Zatollah Asemi

doi:10.1016/j.dnarep.2020.103036

The cross-talk between signaling pathways, noncoding RNAs and DNA damage response: Emerging players in cancer progression

DNA Repair (Amst). 2021 Feb:98:103036. doi: 10.1016/j.dnarep.2020.103036. Epub 2021 Jan 7.

Authors

Affiliations

¹ Department of Biochemistry and Clinical Laboratories, Faculty of Medicine, Tabriz University of Medical Science, Tabriz, Iran; Student's Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
² Department of Biochemistry and Clinical Laboratories, Faculty of Medicine, Tabriz University of Medical Science, Tabriz, Iran.
³ School of Health and Biomedical Sciences, RMIT University, Melbourne, Vic., Australia.
⁴ Solid Tumor Research Center, Urmia University of Medical Sciences, Urmia, Iran.
⁵ Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.
⁶ Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran. Electronic address: Ansarkarimian@gmail.com.
⁷ Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran. Electronic address: asemi_r@yahoo.com.

PMID: 33429260
DOI: 10.1016/j.dnarep.2020.103036

Abstract

The DNA damage response (DDR) pathway's primary purpose is to maintain the genome structure's integrity and stability. A great deal of effort has done to understand the exact molecular mechanisms of non-coding RNAs, such as lncRNA, miRNAs, and circRNAs, in distinct cellular and genomic processes and cancer progression. In this regard, the ncRNAs possible regulatory role in DDR via modulation of key components expression and controlling repair signaling pathway activation is validated. Therefore, in this article, we will discuss the latest developments of ncRNAs contribution in different aspects of DNA repair through regulation of ATM-ATR, P53, and other regulatory signaling pathways.

Keywords: ATM; ATR; DNA damage; DNA repair; Noncoding RNA.

MeSH terms

Ataxia Telangiectasia Mutated Proteins / metabolism
DNA / metabolism
DNA Damage*
DNA Repair*
Humans
RNA, Untranslated / metabolism*
Signal Transduction*

Substances

RNA, Untranslated
DNA
ATR protein, human
Ataxia Telangiectasia Mutated Proteins