Tobacco Worker's Lung: A Neglected Subtype of Hypersensitivity Pneumonitis

Lung. 2021 Feb;199(1):13-19. doi: 10.1007/s00408-020-00416-4. Epub 2021 Jan 11.

Abstract

Tobacco worker's lung (TWL) is a type of hypersensitivity pneumonitis (HP) affecting workers exposed to tobacco leaves and molds in the humidified environment of the tobacco production industry. Limited epidemiological data point to a prevalence of TWL that is not negligible and probably underestimated. As in other types of HP, an acute vs. chronic presentation depends on the pattern of the exposure. Therefore, the clinical presentation can vary from an acute influenza-like syndrome, mostly self-limiting with the removal of the exposure, to an insidious onset of cough, exertional dyspnea, fatigue and weight loss in chronic presentations, where fibrotic changes may be observed. The main treatment strategy is the removal of the exposure to tobacco dust and molds, while the main aim of corticosteroid therapy is to reduce morbidity and prevent complications, namely the development of pulmonary fibrosis and permanent lung dysfunction. Despite the fact that TWL is quite well described, preventive measures are not usually adopted in the tobacco production industry. We present here a state of the art review of this neglected, preventable, but still prevalent and occupational-related subtype of HP.

Keywords: Extrinsic allergic alveolitis; Hypersensitivity pneumonitis; Tobacco worker’s lung.

Publication types

  • Review

MeSH terms

  • Agriculture*
  • Alveolitis, Extrinsic Allergic / diagnosis*
  • Alveolitis, Extrinsic Allergic / epidemiology
  • Alveolitis, Extrinsic Allergic / therapy
  • Glucocorticoids / therapeutic use
  • Humans
  • Occupational Diseases / diagnosis*
  • Occupational Diseases / epidemiology
  • Occupational Diseases / therapy
  • Pulmonary Fibrosis / etiology
  • Respiratory Protective Devices
  • Tobacco Industry*

Substances

  • Glucocorticoids