Probiotics in the add-on treatment of laryngotracheitis: a clinical experience

I La Mantia; M Gelardi; L Drago; S E Aragona; G Cupido; C Vicini; C Berardi; G Ciprandi; Italian Study Group on Upper Respiratory Infections: Albanese G, Anni A, Antoniacomi G, Artoni S,
Asprella G, Azzaro R, Azzolin A, Balduzzi A, Barbarino I, Berardi C, Bertetto BI, Bianchi A, Bianco N,
Bonanno A, Bordonaro C, Brindisi AM, Bucolo S, Bulzomì AG, Caligo G, Capaccio P, Capelli M, Capone A,
Carboni S, Carluccio G, Casaula M, Cassano M, Cavaliere M, Ciabattoni A, Conti A, Cordier A, Cortellessa F,
Costanzo M, Cupido F, D’Ascanio L, Danza C, D’Auria C, De Ciccio M, De Luca C, D’Emila M, Dessi R,
Di Lullo A, D’Urso M, Falcetti S, Falciglia R, Fera G, Ferrari G, Ferraro SM, Fini O, Fiorella M, Floriddia A,
Asprea F, Fusco C, Fuson R, Gallo A, Gambardella T, Gambardella G, Giangregorio F, Gramellini G, Ierace M, 
Ingria F, La Paglia A, Lanza L, Lauletta R, Lavazza P, Leone M, Lovotti P, Luperto P, Maniscalco F,
Marincolo I, Martone R, Melis A, Messina A, Milone V, Mirra N, Montanaro SC, Muià F, Nacci A, Nardello E,
Paderno L, Padovani D, Palma A, Paoletti M, Pedrotti I, Petrillo F, Piccolo M, Pinto P, Policarpo M, Raguso M,
Ranieri A, Romano G, Rondinelli M, Russo C, Scotto Di Santillo L, Sequino G, Serraino EM, Spahiu I, Spanò G,
Stabile C, Stagni G, Stellin M, Tassi S, Tomacelli G, Tombolini A, Valenzise V, Zirone A

Probiotics in the add-on treatment of laryngotracheitis: a clinical experience

J Biol Regul Homeost Agents. 2020 Nov-Dec;34(6 Suppl. 1):35-40.

Authors

I La Mantia¹, M Gelardi², L Drago³, S E Aragona⁴, G Cupido⁵, C Vicini⁶, C Berardi⁷, G Ciprandi⁸; Italian Study Group on Upper Respiratory Infections: Albanese G, Anni A, Antoniacomi G, Artoni S, Asprella G, Azzaro R, Azzolin A, Balduzzi A, Barbarino I, Berardi C, Bertetto BI, Bianchi A, Bianco N, Bonanno A, Bordonaro C, Brindisi AM, Bucolo S, Bulzomì AG, Caligo G, Capaccio P, Capelli M, Capone A, Carboni S, Carluccio G, Casaula M, Cassano M, Cavaliere M, Ciabattoni A, Conti A, Cordier A, Cortellessa F, Costanzo M, Cupido F, D’Ascanio L, Danza C, D’Auria C, De Ciccio M, De Luca C, D’Emila M, Dessi R, Di Lullo A, D’Urso M, Falcetti S, Falciglia R, Fera G, Ferrari G, Ferraro SM, Fini O, Fiorella M, Floriddia A, Asprea F, Fusco C, Fuson R, Gallo A, Gambardella T, Gambardella G, Giangregorio F, Gramellini G, Ierace M, Ingria F, La Paglia A, Lanza L, Lauletta R, Lavazza P, Leone M, Lovotti P, Luperto P, Maniscalco F, Marincolo I, Martone R, Melis A, Messina A, Milone V, Mirra N, Montanaro SC, Muià F, Nacci A, Nardello E, Paderno L, Padovani D, Palma A, Paoletti M, Pedrotti I, Petrillo F, Piccolo M, Pinto P, Policarpo M, Raguso M, Ranieri A, Romano G, Rondinelli M, Russo C, Scotto Di Santillo L, Sequino G, Serraino EM, Spahiu I, Spanò G, Stabile C, Stagni G, Stellin M, Tassi S, Tomacelli G, Tombolini A, Valenzise V, Zirone A⁹

Affiliations

¹ Unit of Otolaryngology, Department of General Surgery and Medical-Surgical Specialties, University of Catania, Catania, Italy.
² Department of Otolaryngology, University of Foggia, Foggia, Italy.
³ Microbiology Department, University of Milan, Milan, Italy.
⁴ Center of Regenerative Medicine, Humanitas Mater Domini, Castellanza (VA), Italy.
⁵ ENT Department, University of Palermo, Palermo, Italy.
⁶ ENT Department, Forlì-Faenza Hospital, Italy, University of Ferrara e Bologna.
⁷ ENT Department, Istituto Clinico Città Studi di Milano, Milan, Italy.
⁸ Allergy Clinic, Casa di Cura Villa Montallegro, Genoa, Italy.
⁹ The Italian Study Group on Upper Respiratory Infections.

PMID: 33426864

Abstract

Laryngotracheitis is a common disease, mainly characterized by dysphonia, cough, and sore throat. The diagnosis is usually based on the clinical ground, and antibiotic therapy is frequently used in clinical practice. However, antibiotics frequently induce intestinal dysbiosis associated with some clinical problems. The current clinical experience was conducted in patients with pharyngotonsillitis and treated with antibiotics. A one-month course of a probiotic mixture (Abincol® containing Lactobacillus plantarum LP01 (1 billion of living cells), Lactobacillus lactis subspecies cremoris LLC02 (800 million living cells), and Lactobacillus delbrueckii LDD01 (200 million living cells), was prescribed in the Group A, and was compared with no add-on treatment, such as the Group B. Patients were evaluated at baseline (T0), at the end of antibiotic treatment (T1), at the end of probiotic course (T2), and at the end of 3-month follow-up (T3). Globally, 833 outpatients with laryngotracheitis were enrolled: 425 in Group A and 408 in Group B. All of them were treated with a 7-10-day course of antibiotic therapy. The probiotic mixture reduced the duration of symptoms associated with antibiotic therapy already at the end of the antibiotic cycle. The intergroup comparison showed that probiotic group patients experienced less fever, tiredness, headache, pain, malaise, diarrhea, and nausea (p<0.001 for all) than control patients at T1. The probiotic course reduced the possible clinical relapse, and the use of additional medications at T2 and T3. In conclusion, the present clinical experience demonstrated that a probiotic mixture containing Lactobacillus plantarum LP01, Lactobacillus lactis subspecies cremoris LLC02, and Lactobacillus delbrueckii subspecies delbrueckii, was able to rapidly reduce symptoms associated with antibiotic therapy in patients with laryngotracheitis.

Keywords: acute; antibiotic therapy; chronic; dysbiosis; pharyngotonsillitis; probiotics.

Publication types

Review

MeSH terms

Anti-Bacterial Agents / therapeutic use
Dysbiosis
Humans
Lactobacillus
Probiotics*

Substances

Anti-Bacterial Agents