Volumetric distribution of perivascular space in relation to mild cognitive impairment

Farshid Sepehrband; Giuseppe Barisano; Nasim Sheikh-Bahaei; Jeiran Choupan; Ryan P Cabeen; Kirsten M Lynch; Malcolm S Crawford; Haoyu Lan; Wendy J Mack; Helena C Chui; John M Ringman; Arthur W Toga; Alzheimer’s Disease Neuroimaging Initiative

doi:10.1016/j.neurobiolaging.2020.12.010

Volumetric distribution of perivascular space in relation to mild cognitive impairment

Neurobiol Aging. 2021 Mar:99:28-43. doi: 10.1016/j.neurobiolaging.2020.12.010. Epub 2020 Dec 16.

Affiliations

¹ Laboratory of NeuroImaging, USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA; Alzheimer's Disease Research Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. Electronic address: Farshid.sepehrband@loni.usc.edu.
² Laboratory of NeuroImaging, USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA; Neuroscience Graduate Program, University of Southern California, Los Angeles, CA, USA.
³ Department of Radiology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA; Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
⁴ Laboratory of NeuroImaging, USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA; Department of Psychology, University of Southern California, Los Angeles, CA, USA.
⁵ Laboratory of NeuroImaging, USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
⁶ Laboratory of NeuroImaging, USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA; School of Medicine, University of California, Irvine, Irvine, CA, USA.
⁷ Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
⁸ Alzheimer's Disease Research Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA; Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
⁹ Laboratory of NeuroImaging, USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA; Alzheimer's Disease Research Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

PMID: 33422892
PMCID: PMC7902350
DOI: 10.1016/j.neurobiolaging.2020.12.010

Abstract

Vascular contributions to early cognitive decline are increasingly recognized, prompting further investigation into the nature of related changes in perivascular spaces (PVS). Using magnetic resonance imaging, we show that, compared to a cognitively normal sample, individuals with early cognitive dysfunction have altered PVS presence and distribution, irrespective of Amyloid-β. Surprisingly, we noted lower PVS presence in the anterosuperior medial temporal lobe (asMTL) (1.29 times lower PVS volume fraction in cognitively impaired individuals, p < 0.0001), which was associated with entorhinal neurofibrillary tau tangle deposition (beta (standard error) = -0.98 (0.4); p = 0.014), one of the hallmarks of early Alzheimer's disease pathology. We also observed higher PVS volume fraction in centrum semi-ovale of the white matter, but only in female participants (1.47 times higher PVS volume fraction in cognitively impaired individuals, p = 0.0011). We also observed PVS changes in participants with history of hypertension (higher in the white matter and lower in the asMTL). Our results suggest that anatomically specific alteration of the PVS is an early neuroimaging feature of cognitive impairment in aging adults, which is differentially manifested in female.

Keywords: Alzheimer’s disease; Clearance system; Cognitive decline; Perivascular space.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Aging / pathology
Amyloid / metabolism
Cognitive Dysfunction / pathology*
Female
Glymphatic System / diagnostic imaging
Glymphatic System / metabolism
Glymphatic System / pathology*
Humans
Hypertension / pathology
Magnetic Resonance Imaging
Male
Neurofibrillary Tangles / metabolism
Neuroimaging
Organ Size
Sex Characteristics
White Matter / pathology
tau Proteins / metabolism

Substances

Amyloid
tau Proteins

Volumetric distribution of perivascular space in relation to mild cognitive impairment

Authors

Affiliations

Abstract

Publication types

MeSH terms

Substances

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