The emerging role of one-carbon metabolism in T cells

Henry Kurniawan; Takumi Kobayashi; Dirk Brenner

doi:10.1016/j.copbio.2020.12.001

The emerging role of one-carbon metabolism in T cells

Curr Opin Biotechnol. 2021 Apr:68:193-201. doi: 10.1016/j.copbio.2020.12.001. Epub 2021 Jan 7.

Authors

Henry Kurniawan¹, Takumi Kobayashi¹, Dirk Brenner²

Affiliations

¹ Experimental & Molecular Immunology, Department of Infection and Immunity, Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg; Immunology and Genetics, Luxembourg Centre for System Biomedicine (LCSB), University of Luxembourg, Belval, Luxembourg.
² Experimental & Molecular Immunology, Department of Infection and Immunity, Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg; Immunology and Genetics, Luxembourg Centre for System Biomedicine (LCSB), University of Luxembourg, Belval, Luxembourg; Odense Research Center for Anaphylaxis, Department of Dermatology and Allergy Center, Odense University Hospital, University of Southern Denmark, Odense, Denmark. Electronic address: dirk.brenner@lih.lu.

PMID: 33422815
DOI: 10.1016/j.copbio.2020.12.001

Abstract

One-carbon metabolism (1CM) supports multiple biological functions, providing 1C units for nucleotide synthesis, epigenetic maintenance, and redox regulation. Although much has been deciphered about the relationship between disruption of 1CM and various diseases, our understanding of 1CM's involvement in the regulation of the immune system is only now evolving. In this review, we summarize key checkpoints of 1CM pathways that govern cellular activities. We also report on recent findings regarding the role of 1CM in T cells and discuss several promising avenues requiring future investigation.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Carbon*
Oxidation-Reduction
T-Lymphocytes*

Substances

Carbon