Proteinase release from activated neutrophils in mechanically ventilated patients with non-COVID-19 and COVID-19 pneumonia

Seda Seren; Lohann Derian; Irem Keleş; Antoine Guillon; Adam Lesner; Loïc Gonzalez; Thomas Baranek; Mustapha Si-Tahar; Sylvain Marchand-Adam; Dieter E Jenne; Christophe Paget; Youenn Jouan; Brice Korkmaz

doi:10.1183/13993003.03755-2020

Proteinase release from activated neutrophils in mechanically ventilated patients with non-COVID-19 and COVID-19 pneumonia

Eur Respir J. 2021 Apr 29;57(4):2003755. doi: 10.1183/13993003.03755-2020. Print 2021 Apr.

Authors

Seda Seren¹, Lohann Derian^{1

2}, Irem Keleş^{1

3

2}, Antoine Guillon^{1

4}, Adam Lesner⁵, Loïc Gonzalez¹, Thomas Baranek¹, Mustapha Si-Tahar¹, Sylvain Marchand-Adam^{1

6}, Dieter E Jenne⁷, Christophe Paget¹, Youenn Jouan^{1

4}, Brice Korkmaz¹

Affiliations

¹ INSERM UMR-1100, "Research Center for Respiratory Diseases", University of Tours, Tours, France.
² Equal contribution.
³ Yeditepe University, Istanbul, Turkey.
⁴ Intensive Care Unit, Tours University Hospital, Tours, France.
⁵ Faculty of Chemistry, University of Gdansk, Gdansk, Poland.
⁶ Dept of Pneumology and Respiratory Functional Exploration, Tours University Hospital, Tours, France.
⁷ Comprehensive Pneumology Center, Institute of Lung Biology and Disease, German Center for Lung Research (DZL) 81377 Munich and Max Planck Institute of Neurobiology, Planegg-Martinsried, Germany.

Abstract

COVID-19 ARDS is associated with release of biologically active neutrophil elastase-related proteinases to the airways and blood at a comparable level to non-COVID ARDS https://bit.ly/3nihveh

Publication types

Letter

MeSH terms

COVID-19*
Humans
Neutrophils
Peptide Hydrolases
Respiration, Artificial
SARS-CoV-2

Substances

Peptide Hydrolases