Drug-Induced Acute Kidney Injury: A Study from the French Medical Administrative and the French National Pharmacovigilance Databases Using Capture-Recapture Method

Anne-Lise Rolland; Anne-Sophie Garnier; Katy Meunier; Guillaume Drablier; Marie Briet

doi:10.3390/jcm10020168

Drug-Induced Acute Kidney Injury: A Study from the French Medical Administrative and the French National Pharmacovigilance Databases Using Capture-Recapture Method

J Clin Med. 2021 Jan 6;10(2):168. doi: 10.3390/jcm10020168.

Authors

Anne-Lise Rolland¹, Anne-Sophie Garnier^{2

3}, Katy Meunier¹, Guillaume Drablier⁴, Marie Briet^{2

4}

Affiliations

¹ Département d'Information Médicale, Centre Hospitalo-Universitaire d'Angers, 49100 Angers, France.
² Service de Néphrologie-Dialysis-Transplantation, Centre Hospitalo-Universitaire d'Angers, 49100 Angers, France.
³ Laboratoire MitoVasc, INSERM U1083, CNRS UMR 6015, Université d'Angers, 49100 Angers, France.
⁴ Service de Pharmacologie-Toxicologie et Centre Régional de Pharmacovigilance, Centre Hospitalo-Universitaire d'Angers, 49100 Angers, France.

Abstract

Background: Acute kidney injury (AKI) is a public health concern. Among the pathological situations leading to AKI, drugs are preventable factors but are still under-notified. We aimed to provide an overview of drug-induced AKI (DIAKI) using pharmacovigilance and medical administrative databases Methods: A query of the PMSI database (French Medical Information System Program) of adult inpatient hospital stays between 1 January 2017 and 31 December 2018 was performed using ICD-10 (International Classification of Diseases 10th revision) codes to identify AKI cases which were reviewed by a nephrologist and a pharmacovigilance expert to identify DIAKI cases. In parallel, DIAKIs notified in the French Pharmacovigilance Database (FPVDB) were collected. A capture-recapture method was performed to estimate the total number of DIAKIs.

Results: The estimated total number of DIAKIs was 521 (95%CI 480; 563), representing 20.0% of all AKIs. The notification was at a rate of 12.9% (95%CI 10.0; 15.8). According to the KDIGO classification, 50.2% of the DIAKI cases were stage 1 and 49.8% stage 2 and 3. The mortality rate was 11.1% and 9.6% required hemodialysis.

Conclusion: This study showed that drugs are involved in a significant proportion of patients developing AKI during a hospital stay and emphasizes the severity of DIAKI cases.

Keywords: French medical information system program; French pharmacovigilance database; KDIGO; capture-recapture method; drug-induced acute kidney injury; notification rate.