Breaking the Rules: Protein Sculpting in NEIL2 Regulation

Susan E Tsutakawa; Altaf H Sarker

doi:10.1016/j.str.2020.12.011

Breaking the Rules: Protein Sculpting in NEIL2 Regulation

Structure. 2021 Jan 7;29(1):1-2. doi: 10.1016/j.str.2020.12.011.

Authors

Susan E Tsutakawa¹, Altaf H Sarker²

Affiliations

¹ Molecular Biophysics and Integrated Bioimaging, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA. Electronic address: setsutakawa@lbl.gov.
² Biological Systems and Engineering, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.

Abstract

The canonical DNA glycosylase role is global base damage repair but includes functions in epigenetic gene regulation, immune response modulation, replication, and transcription. In this issue of Structure, Eckenroth et al. (2020) present the NEIL2 glycosylase structure. Its catalytic domain flexibility differentiates it from most other glycosylases and suggests novel regulatory mechanisms.

Publication types

Research Support, N.I.H., Extramural
Comment

MeSH terms

Animals
DNA
DNA Damage
DNA Glycosylases* / genetics
DNA Glycosylases* / metabolism
DNA Repair
DNA-(Apurinic or Apyrimidinic Site) Lyase / genetics
DNA-(Apurinic or Apyrimidinic Site) Lyase / metabolism

Substances

DNA
DNA Glycosylases
DNA-(Apurinic or Apyrimidinic Site) Lyase

Abstract

Publication types

MeSH terms

Substances

Grants and funding