The Rise of Molecular Glues

Stuart L Schreiber

doi:10.1016/j.cell.2020.12.020

The Rise of Molecular Glues

Cell. 2021 Jan 7;184(1):3-9. doi: 10.1016/j.cell.2020.12.020.

Author

Stuart L Schreiber¹

Affiliation

¹ Department of Chemistry & Chemical Biology, Harvard University, 12 Oxford St, Cambridge, MA 02138, USA; Chemical Biology & Therapeutics Science Program, Broad Institute, 415 Main St, Cambridge, MA 02142, USA. Electronic address: stuart_schreiber@harvard.edu.

PMID: 33417864
DOI: 10.1016/j.cell.2020.12.020

Abstract

2021 marks the 30th anniversary of the revelation that cyclosporin A and FK506 act in a way previously not seen-as "molecular glues" that induce neo-protein-protein associations. As a torrent of new molecular-glue probes and medicines are fueling interest in this field, I explore the arc of this story.

MeSH terms

Biological Products / chemistry
Biological Products / pharmacology*
Cyclosporine / pharmacology
Immunosuppressive Agents / pharmacology
Tacrolimus / chemistry
Tacrolimus / pharmacology

Substances

Biological Products
Immunosuppressive Agents
Cyclosporine
Tacrolimus