Bioprinting for the Biologist

Andrew C Daly; Margaret E Prendergast; Alex J Hughes; Jason A Burdick

doi:10.1016/j.cell.2020.12.002

Bioprinting for the Biologist

Cell. 2021 Jan 7;184(1):18-32. doi: 10.1016/j.cell.2020.12.002.

Authors

Andrew C Daly¹, Margaret E Prendergast¹, Alex J Hughes², Jason A Burdick³

Affiliations

¹ Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA.
² Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, PA 19104, USA.
³ Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: burdick2@seas.upenn.edu.

Abstract

Building tissues from scratch to explore entirely new cell configurations could revolutionize fundamental understanding in biology. Bioprinting is an emerging technology to do this. Although typically applied to engineer tissues for therapeutic tissue repair or drug screening, there are many opportunities for bioprinting within biology, such as for exploring cellular crosstalk or cellular morphogenesis. The overall goals of this Primer are to provide an overview of bioprinting with the biologist in mind, outline the steps in extrusion bioprinting (the most widely used and accessible technology), and discuss alternative bioprinting technologies and future opportunities for bioprinting in biology.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Review

MeSH terms

Biology*
Bioprinting*
Disease
Humans
Ink
Tissue Engineering

Grants and funding

R35 GM133380/GM/NIGMS NIH HHS/United States