Novel IL36RN Mutation Identified in Pediatric-Onset Generalized Pustular Psoriasis Causes IL36 Antagonist Degradation

Hongmei Li; Dan Liao; Shasha Meng; Jingru Liu; Songyang Li; Sili Ni; Yunfei Xu; Yong Zhao; Weihui Zhou

doi:10.1007/s10875-020-00944-x

Novel IL36RN Mutation Identified in Pediatric-Onset Generalized Pustular Psoriasis Causes IL36 Antagonist Degradation

J Clin Immunol. 2021 Apr;41(3):701-704. doi: 10.1007/s10875-020-00944-x. Epub 2021 Jan 7.

Authors

Hongmei Li^{1

2}, Dan Liao^{3

4}, Shasha Meng³, Jingru Liu³, Songyang Li³, Sili Ni⁵, Yunfei Xu³, Yong Zhao⁶, Weihui Zhou⁷

Affiliations

¹ Pediatric Research Institute; Ministry of Education Key Laboratory of Child Development and Disorders; Chongqing Key Laboratory of Translational Medical Research in Cognitive Development and Learning and Memory Disorders; National Clinical Research Center for Child Health and Disorders; China International Science and Technology Cooperation base of Child Development and Critical Disorders, Children's Hospital of Chongqing Medical University, Chongqing, People's Republic of China. hongmei69@hotmail.com.
² Department of Dermatology, Children's Hospital of Chongqing Medical University, Chongqing, People's Republic of China. hongmei69@hotmail.com.
³ Pediatric Research Institute; Ministry of Education Key Laboratory of Child Development and Disorders; Chongqing Key Laboratory of Translational Medical Research in Cognitive Development and Learning and Memory Disorders; National Clinical Research Center for Child Health and Disorders; China International Science and Technology Cooperation base of Child Development and Critical Disorders, Children's Hospital of Chongqing Medical University, Chongqing, People's Republic of China.
⁴ Department of Laboratory Medicine, Daping Hospital, Army Medical University, Chongqing, People's Republic of China.
⁵ Department of Dermatology, Children's Hospital of Chongqing Medical University, Chongqing, People's Republic of China.
⁶ Beijing Beike Deyuan Bio-Pharm Technology Co. Ltd, No. 3 Building, No. 7 Fengxian Middle St. Haidian District, Beijing, 100094, People's Republic of China.
⁷ Pediatric Research Institute; Ministry of Education Key Laboratory of Child Development and Disorders; Chongqing Key Laboratory of Translational Medical Research in Cognitive Development and Learning and Memory Disorders; National Clinical Research Center for Child Health and Disorders; China International Science and Technology Cooperation base of Child Development and Critical Disorders, Children's Hospital of Chongqing Medical University, Chongqing, People's Republic of China. zwh@hospital.cqmu.edu.cn.

PMID: 33415665
DOI: 10.1007/s10875-020-00944-x

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Age of Onset
Alleles
Biopsy
Child
DNA Mutational Analysis
Female
Genetic Association Studies* / methods
Genetic Predisposition to Disease*
Genotype
Humans
Interleukins / chemistry
Interleukins / genetics*
Interleukins / metabolism
Mutation*
Phenotype
Proteolysis
Psoriasis / diagnosis*
Psoriasis / genetics*
Psoriasis / therapy
Skin / pathology
Symptom Assessment

Substances

IL36RN protein, human
Interleukins