Non-coding RNAs: emerging regulators of glucose metabolism in hepatocellular carcinoma

Yongting Lai; Hairong Huang; Mubalake Abudoureyimu; Xinrong Lin; Chuan Tian; Ting Wang; Xiaoyuan Chu; Rui Wang

Non-coding RNAs: emerging regulators of glucose metabolism in hepatocellular carcinoma

Am J Cancer Res. 2020 Dec 1;10(12):4066-4084. eCollection 2020.

Authors

Yongting Lai¹, Hairong Huang², Mubalake Abudoureyimu³, Xinrong Lin³, Chuan Tian³, Ting Wang³, Xiaoyuan Chu^{1

3}, Rui Wang^{1

3}

Affiliations

¹ Department of Medical Oncology, Jinling Hospital, The First School of Clinical Medicine, Southern Medical University Nanjing, China.
² Department of Cardiothoracic Surgery, Jinling Hospital Nanjing, China.
³ Department of Medical Oncology, School of Medicine, Jinling Hospital, Nanjing University Nanjing, China.

PMID: 33414986
PMCID: PMC7783776

Abstract

Reprogramming of metabolism is one of the hallmarks of cancer, among which glucose metabolism dysfunction is the most prominent feature. The glucose metabolism of tumor cells is significantly different from that of normal cells. Glucose metabolism reprogramming of hepatocellular carcinoma (HCC) has become an important research hotspot in the field of HCC, a variety of tumor metabolic interventions have been applied clinically. Moreover, various Non-coding RNAs (ncRNAs) including microRNAs (miRNAs), long non-coding (lncRNAs) as well as circular RNAs (circRNAs), have recently been proved to play potential roles in glucose metabolism. This review summarizes the effects of ncRNAs on HCC that participate in glucose metabolism and discuss the related mechanisms to find potential and effective targeted treatments for HCC.

Keywords: Hepatocellular carcinoma; circular RNAs; glucose metabolism; glycolysis; long non-coding RNAs; microRNAs; non-coding RNA.

Publication types

Review