Chemical constituents of Chaenomeles sinensis twigs and their biological activity

Joon Min Cha; Dong Hyun Kim; Lalita Subedi; Zahra Khan; Sang Un Choi; Sun Yeou Kim; Chung Sub Kim

doi:10.3762/bjoc.16.257

Chemical constituents of Chaenomeles sinensis twigs and their biological activity

Beilstein J Org Chem. 2020 Dec 17:16:3078-3085. doi: 10.3762/bjoc.16.257. eCollection 2020.

Authors

Joon Min Cha^#¹, Dong Hyun Kim^#¹, Lalita Subedi², Zahra Khan², Sang Un Choi³, Sun Yeou Kim^{2

4}, Chung Sub Kim¹

Affiliations

¹ School of Pharmacy, Sungkyunkwan University, Suwon 16419, Republic of Korea.
² College of Pharmacy, Gachon University, #191, Hambakmoero, Yeonsu-gu, Incheon 21936, Republic of Korea.
³ Korea Research Institute of Chemical Technology, Daejeon 34114, Republic of Korea.
⁴ Gachon Institute of Pharmaceutical Science, Gachon University, Incheon 21936, Republic of Korea.

^# Contributed equally.

Abstract

A new megastigmane-type norsesquiterpenoid glycoside, chaemeloside (1), was isolated from the twigs of Chaenomeles sinensis together with 11 known phytochemicals through chromatographic methods. The chemical structure of the new isolate 1 was determined by conventional 1D and 2D NMR data analysis, ECD experiment, hydrolysis followed by a modified Mosher's method, and LC-MS analysis. The characterized compounds' biological effects including cytotoxicity against cancer cell lines, antineuroinflammatory activity, and potential neurotrophic effect were evaluated.

Keywords: Chaenomeles sinensis; antineuroinflammation; cytotoxicity; megastigmane; neurotrophic effect.

Grants and funding

This work was supported by the National Research Foundation (NRF) of Korea grant funded by the government of Korea (MSIT) (No. 2020R1F1A1073119).