Abstract
Proteinuria is one of the most typical manifestations of kidney involvement in Systemic Lupus Erythematosus (SLE). We report the case of a 23-year-old woman with a 6-year-long history of SLE presenting with proteinuria after a three-year remission on hydroxychloroquine. Kidney histological examination showed alterations inconsistent with lupus nephritis and suggestive of hydroxychloroquine toxicity or Fabry disease. The latter was confirmed by genetic assay.
Keywords:
Fabry disease; Systemic lupus erythematosus; hydroxychloroquine; proteinuria; renal biopsy.
MeSH terms
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Antirheumatic Agents / administration & dosage
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Antirheumatic Agents / therapeutic use
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Antirheumatic Agents / toxicity
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Biopsy
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Diagnosis, Differential
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Enzyme Replacement Therapy / methods
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Fabry Disease / diagnosis
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Fabry Disease / genetics*
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Fabry Disease / therapy
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Fabry Disease / urine
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Female
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Humans
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Hydroxychloroquine / administration & dosage
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Hydroxychloroquine / therapeutic use
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Hydroxychloroquine / toxicity*
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Kidney / drug effects
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Kidney / pathology
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Lupus Erythematosus, Systemic / diagnosis*
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Lupus Erythematosus, Systemic / drug therapy
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Lupus Erythematosus, Systemic / urine
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Lupus Nephritis / chemically induced*
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Lupus Nephritis / pathology
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Lupus Nephritis / urine
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Proteinuria / etiology*
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Remission Induction
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Treatment Outcome
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Young Adult
Substances
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Antirheumatic Agents
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Hydroxychloroquine