Identification and prioritization of the potent components for combined exposure of multiple persistent organic pollutants associated with gestational diabetes mellitus

Xin Liu; Lei Zhang; Liangkai Chen; Jingguang Li; Jun Wang; Yunfeng Zhao; Liegang Liu; Yongning Wu

doi:10.1016/j.jhazmat.2020.124905

Identification and prioritization of the potent components for combined exposure of multiple persistent organic pollutants associated with gestational diabetes mellitus

J Hazard Mater. 2021 May 5:409:124905. doi: 10.1016/j.jhazmat.2020.124905. Epub 2021 Jan 4.

Authors

Xin Liu¹, Lei Zhang², Liangkai Chen³, Jingguang Li⁴, Jun Wang⁵, Yunfeng Zhao², Liegang Liu³, Yongning Wu¹

Affiliations

¹ NHC Key Laboratory of Food Safety Risk Assessment, Food Safety Research Unit (2019RU014) of Chinese Academy of Medical Science, China National Center for Food Safety Risk Assessment, Beijing 100021, China; Institute of Food Science and Engineering, Wuhan Polytechnic University, Wuhan 430023, China.
² NHC Key Laboratory of Food Safety Risk Assessment, Food Safety Research Unit (2019RU014) of Chinese Academy of Medical Science, China National Center for Food Safety Risk Assessment, Beijing 100021, China.
³ Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430023, China.
⁴ NHC Key Laboratory of Food Safety Risk Assessment, Food Safety Research Unit (2019RU014) of Chinese Academy of Medical Science, China National Center for Food Safety Risk Assessment, Beijing 100021, China. Electronic address: lijg@cfsa.net.cn.
⁵ Shenzhen Center for Chronic Disease Control, Shenzhen 518020, China.

PMID: 33412473
DOI: 10.1016/j.jhazmat.2020.124905

Abstract

Persistent organic pollutants (POPs) remain a major point of concern worldwide, and surveillance monitoring of these contaminants presents a significant challenge. Here, we conducted an assessment of combined exposure to multiple POPs components [10 perfluoroalkyl acids (PFAAs), seven polybrominated diphenyl ethers (PBDEs), six polychlorinated biphenyls (PCBs) and 29 dioxin-like compounds (DLCs)] in relation to gestational diabetes mellitus (GDM) risk, and determined the identification and prioritization of potent components in these POPs mixtures. The results indicated a significant mixture effect and the combined exposure index estimated from multiple POPs components was associated with GDM and glucose homeostasis (P < 0.001). Based on the mixture effects on GDM, the procedure of prioritization identified DLCs as the components of the greatest concern, although at the lowest body burden in the population compared with PBDEs, PFAAs, and PCBs. For glucose homeostasis, BDE-153 was the chemical of top-ranked priority of concern. The final effect-based prioritized list of POPs was DLCs > PBDEs >PFAAs > PCBs. This prioritization is important for developing a more cost-effective regulation framework focusing on the POPs components of the greatest concern to human health.

Keywords: Combined exposure; GDM risk; Glucose homeostasis; POPs mixture; Prioritization.

MeSH terms

Diabetes, Gestational* / chemically induced
Environmental Pollutants* / toxicity
Female
Halogenated Diphenyl Ethers / analysis
Halogenated Diphenyl Ethers / toxicity
Humans
Persistent Organic Pollutants
Polychlorinated Biphenyls* / analysis
Polychlorinated Biphenyls* / toxicity
Pregnancy

Substances

Environmental Pollutants
Halogenated Diphenyl Ethers
Polychlorinated Biphenyls