Communication-based interventions have been linked to improved health and social outcomes among underserved populations. Migrant women in sex work face serious health and social inequities, including risks of HIV and other sexually transmitted infections (STIs) and violence. Given gaps in evidence about health communication among migrant sex workers and the potential for communication-based interventions to promote health and safety, this qualitative study investigates experiences with accessing and sharing information regarding HIV/STI prevention, sexual and reproductive health, and physical safety among migrant sex workers at the Mexico-Guatemala border. Findings suggest that participatory peer-based, workplace, and m-health communication interventions could facilitate access to HIV/STI prevention, and to sexual and reproductive health/safety resources for migrant women involved in sex work, while strengthening peer support networks and social cohesion. To have long-lasting results, such interventions must be complemented by broader structural changes, including sex work and migration law reforms, increased community mobilization, and improved working conditions.