Mycotoxins are toxic compounds naturally produced by certain types of fungi. The contamination of mycotoxins can occur on numerous foodstuffs, including cereals, nuts, fruits, and spices, and pose a major threat to humans and animals by causing acute and chronic toxic effects. In this regard, reliable techniques for accurate and sensitive detection of mycotoxins in agricultural products and food samples are urgently needed. As an advanced analytical tool, surface-enhanced Raman spectroscopy (SERS), presents several major advantages, such as ultrahigh sensitivity, rapid detection, fingerprint-type information, and miniaturized equipment. Benefiting from these merits, rapid growth has been observed under the topic of SERS-based mycotoxin detection. This review provides a comprehensive overview of the recent achievements in this area. The progress of SERS-based label-free detection, aptasensor, and immunosensor, as well as SERS combined with other techniques, has been summarized, and in-depth discussion of the remaining challenges has been provided, in order to inspire future development of translating the techniques invented in scientific laboratories into easy-to-operate analytic platforms for rapid detection of mycotoxins.
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