Spinal motor mapping by epidural stimulation of lumbosacral posterior roots in humans

Ursula S Hofstoetter; Ivan Perret; Aymeric Bayart; Peter Lackner; Heinrich Binder; Brigitta Freundl; Karen Minassian

doi:10.1016/j.isci.2020.101930

Spinal motor mapping by epidural stimulation of lumbosacral posterior roots in humans

iScience. 2020 Dec 11;24(1):101930. doi: 10.1016/j.isci.2020.101930. eCollection 2021 Jan 22.

Authors

Ursula S Hofstoetter¹, Ivan Perret¹, Aymeric Bayart¹, Peter Lackner², Heinrich Binder², Brigitta Freundl², Karen Minassian¹

Affiliations

¹ Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, 1090 Vienna, Austria.
² Neurological Center, Klinik Penzing Wiener Gesundheitsverbund, 1140 Vienna, Austria.

Abstract

Epidural electrical stimulation of the spinal cord is an emergent strategy for the neurological recovery of lower-extremity motor function. Motoneuron pools are thought to be recruited by stimulation of posterior roots. Here, we linked electromyographic data of epidurally evoked lower-extremity responses of 34 individuals with upper motoneuron disorders to a population model of the spinal cord constructed using anatomical parameters of thousands of individuals. We identified a relationship between segmental stimulation sites and activated spinal cord segments, which made spinal motor mapping from epidural space possible despite the complex anatomical interface imposed by the posterior roots. Our statistical approach provided evidence for low-threshold sites of posterior roots and effects of monopolar and bipolar stimulation previously predicted by computer modeling and allowed us to test the impact of different upper motoneuron disorders on the evoked responses. Finally, we revealed a statistical association between intraoperative and postoperative mapping of the spinal cord.

Keywords: Clinical Neuroscience; Nervous System Anatomy; Neuroanatomy; Neuroscience.