Multi-layer optical fiber surface plasmon resonance biosensor based on a sandwich structure of polydopamine-MoSe2@Au nanoparticles-polydopamine

Kun Liu; Jiahang Zhang; Junfeng Jiang; Tianhua Xu; Shuang Wang; Pengxiang Chang; Zhao Zhang; Jinying Ma; Tiegen Liu

doi:10.1364/BOE.409535

Multi-layer optical fiber surface plasmon resonance biosensor based on a sandwich structure of polydopamine-MoSe₂@Au nanoparticles-polydopamine

Biomed Opt Express. 2020 Nov 3;11(12):6840-6851. doi: 10.1364/BOE.409535. eCollection 2020 Dec 1.

Authors

Kun Liu^{1

2

3}, Jiahang Zhang^{1

2

3}, Junfeng Jiang^{1

2

3}, Tianhua Xu^{1

2

3}, Shuang Wang^{1

2

3}, Pengxiang Chang^{1

2

3}, Zhao Zhang^{1

2

3}, Jinying Ma^{1

2

3}, Tiegen Liu^{1

2

3}

Affiliations

¹ School of Precision Instruments and Optoelectronics Engineering, Tianjin University, Tianjin 300072, China.
² Key Laboratory of Optoelectronics Information Technology, Ministry of Education, Tianjin University, Tianjin 300072, China.
³ Tianjin Optical Fiber Sensing Engineering Center, Institute of Optical Fiber Sensing, Tianjin University, Tianjin 300072, China.

Abstract

An all-optical fiber multi-layer surface plasmon resonance (SPR) biosensor based on a sandwich structure of polydopamine-MoSe₂@Au nanoparticles-polydopamine (PDA-MoSe₂@AuNPs-PDA) was designed for the detection of specific immunoreactions. By optimizing the multi-layer structure and the ratio of MoSe₂: AuNPs, a sensitivity of 5117.59 nm/RIU has been obtained, which is more than double that of the only Au-filmed optical fiber SPR sensor. A large surface area was produced by integrating the MoSe₂ primitive unit cell and the AuNPs into a hybrid plasmonic nanostructure of MoSe₂@AuNPs, leading to optical fiber SPR signal amplification. The nanostructure of MoSe₂@AuNPs was surrounded by the PDA layer to guarantee the efficient immobilization of the protein molecules on the optical fiber by strong covalent bond. This biosensor achieved a detection limit of 54.05 ng/mL for detecting the goat-anti-rabbit IgG, which demonstrated enhancements of 12.1%, 23.3% and 184.6% in comparison with three reported SPR biosensors decorated with PDA-AuNPs-PDA, PDA and Cysteamine-MoSe₂@AuNPs-Cysteamine nanostructure, respectively. This biosensor achieved favorable selectivity and outstanding sensitivity compared with the reported SPR immuno-sensors, which will provide a miniaturized, rapid-response and label-free optical fiber bio-sensing platform for clinical diagnosis in the future.