Potential Role and Excretion Level of Urinary Transferrin, KIM-1, RBP, MCP-1 and NGAL Markers in Diabetic Nephropathy

Khalid Siddiqui; Salini Scaria Joy; Teena Puthiyaparampil George; Muhammad Mujammami; Assim A Alfadda

doi:10.2147/DMSO.S282166

Potential Role and Excretion Level of Urinary Transferrin, KIM-1, RBP, MCP-1 and NGAL Markers in Diabetic Nephropathy

Diabetes Metab Syndr Obes. 2020 Dec 31:13:5103-5111. doi: 10.2147/DMSO.S282166. eCollection 2020.

Authors

Khalid Siddiqui¹, Salini Scaria Joy¹, Teena Puthiyaparampil George¹, Muhammad Mujammami^{1

2

3}, Assim A Alfadda^{1

3

4}

Affiliations

¹ Strategic Center for Diabetes Research, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
² University Diabetes Center, King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia.
³ Department of Medicine, College of Medicine, and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia.
⁴ Obesity Research Center, College of Medicine, King Saud University, Riyadh, Saudi Arabia.

Abstract

Background: Analyzing urinary biomarkers may provide better insight into pathophysiological mechanisms of diabetic kidney diseases. The study aimed to analyze the pattern of selected excreted urinary biomarkers and its correlation with albuminuria and estimated glomerular filtration rate (eGFR) in patients with type 2 diabetes.

Methods: A total of 185 patients with type 2 diabetes were categorized according to KDIGO guideline based on albuminuria and eGFR. The urinary markers (transferrin, KIM-1, RBP, MCP-1 and NGAL) were measured by ELISA.

Results: The urinary markers were associated with eGFR (total protein/Cr, p=0.001; RBP/Cr, p=0.007; MCP-1/Cr, p=0.023; NGAL/Cr, p=0.011) and albuminuria (total protein/Cr, p<0.001; transferrin, p<0.001; RBP/Cr, p<0.001; MCP-1/Cr, p<0.001; NGAL/Cr, p=0.002).

Conclusion: The urinary marker levels (total protein, RBP, MCP-1, and NGAL) are elevated with severity of kidney damage and expressed more in progressive renal impairment.

Keywords: albuminuria; diabetic kidney disease; kidney injury molecule-1; monocyte chemoattractant protein-1; neutrophil gelatinase-associated lipocalin; retinol-binding protein; transferrin; urinary markers.