Setting Up an Automated Biomanufacturing Laboratory

Methods Mol Biol. 2021:2229:137-155. doi: 10.1007/978-1-0716-1032-9_5.

Abstract

Laboratory automation is a key enabling technology for genetic engineering that can lead to higher throughput, more efficient and accurate experiments, better data management and analysis, decrease in the DBT (Design, Build, and Test) cycle turnaround, increase of reproducibility, and savings in lab resources. Choosing the correct framework among so many options available in terms of software, hardware, and skills needed to operate them is crucial for the success of any automation project. This chapter explores the multiple aspects to be considered for the solid development of a biofoundry project including available software and hardware tools, resources, strategies, partnerships, and collaborations in the field needed to speed up the translation of research results to solve important society problems.

Keywords: Hardware; Laboratory automation; Liquid handling; Machine learning; Metabolic engineering; Reproducibility; Software; Standardization; Synthetic biology; Throughput.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Automation, Laboratory
  • Genetic Engineering / instrumentation
  • Genetic Engineering / methods*
  • High-Throughput Screening Assays
  • Machine Learning
  • Software
  • Synthetic Biology
  • Systems Biology / instrumentation
  • Systems Biology / methods*