Murine Models of Hematopoietic Cell Transplantation to Investigate Fungal Infections

Methods Mol Biol. 2021:2260:207-214. doi: 10.1007/978-1-0716-1182-1_14.

Abstract

Animal models are fundamental to unravel the complex nature of fungal infections in the host context. Here, a versatile murine model of hematopoietic cell transplantation (HCT) is described. This model can be used to investigate the establishment and progression of fungal infections after HCT and to elucidate how different transplant variables affect the recovery of host immunity.

Keywords: Animal model of hematopoietic cell transplantation; Animal models of infection; Fungal infection.

MeSH terms

  • Animals
  • Disease Models, Animal
  • Flow Cytometry
  • Fungi / immunology
  • Fungi / pathogenicity*
  • Hematopoietic Stem Cell Transplantation / adverse effects*
  • Host-Pathogen Interactions
  • Immunocompromised Host*
  • Mice
  • Mice, Inbred BALB C
  • Mice, Inbred C57BL
  • Mice, Inbred DBA
  • Mycoses / immunology
  • Mycoses / microbiology*