Soluble Interleukin-2 Receptor Is a Promising Serum Biomarker for Granulomatous Disease in Common Variable Immune Deficiency

Astrid C van Stigt; Virgil A S H Dalm; Nicole M A Nagtzaam; Damian A van Rijswijk; Barbara H Barendregt; P Martin van Hagen; Hanna IJspeert; Willem A Dik

doi:10.1007/s10875-020-00947-8

Soluble Interleukin-2 Receptor Is a Promising Serum Biomarker for Granulomatous Disease in Common Variable Immune Deficiency

J Clin Immunol. 2021 Apr;41(3):694-697. doi: 10.1007/s10875-020-00947-8. Epub 2021 Jan 6.

Authors

Astrid C van Stigt^{1

2

3}, Virgil A S H Dalm^{1

2

3}, Nicole M A Nagtzaam^{1

3}, Damian A van Rijswijk^{1

3}, Barbara H Barendregt^{1

3}, P Martin van Hagen^{1

2

3}, Hanna IJspeert^#^{1

3}, Willem A Dik^#^{4

5}

Affiliations

¹ Department of Immunology, Laboratory Medical Immunology, Erasmus University Medical Center, Rotterdam, the Netherlands.
² Department of Internal Medicine, Division of Clinical Immunology, Erasmus University Medical Center, Rotterdam, the Netherlands.
³ Academic Center for Rare Immunological Diseases (RIDC), Erasmus University Medical Center, Rotterdam, the Netherlands.
⁴ Department of Immunology, Laboratory Medical Immunology, Erasmus University Medical Center, Rotterdam, the Netherlands. w.dik@erasmusmc.nl.
⁵ Academic Center for Rare Immunological Diseases (RIDC), Erasmus University Medical Center, Rotterdam, the Netherlands. w.dik@erasmusmc.nl.

^# Contributed equally.

No abstract available

Publication types

Letter

MeSH terms

Biomarkers*
CD4 Lymphocyte Count
CD4-Positive T-Lymphocytes / immunology
CD4-Positive T-Lymphocytes / metabolism
Common Variable Immunodeficiency / complications*
Common Variable Immunodeficiency / etiology
Disease Management
Disease Susceptibility
Granuloma / blood*
Granuloma / diagnosis
Granuloma / etiology*
Humans
Prognosis
ROC Curve
Receptors, Interleukin-2 / blood*

Substances

Biomarkers
Receptors, Interleukin-2