Insufficient thrombopoietin due to hepatic dysmature results in thrombocytopenia in small-for-gestational-age rats

Br J Haematol. 2021 Feb;192(4):e105-e108. doi: 10.1111/bjh.17294. Epub 2021 Jan 6.

Authors

Satoru Takeshita^{1

2}, Hiroki Kakita^{1

2}, Kohki Toriuchi¹, Hiromasa Aoki¹, Hiroko Ueda², Akihiko Wakatsuki³, Yasumasa Yamada², Mineyoshi Aoyama¹

Affiliations

¹ Department of Pathobiology, Nagoya City University Graduate School of Pharmaceutical Sciences, 3-1 Tanabe-dori, Mizoho-ku, Nagoya, Aichi, 467-8603, Japan.
² Department of Perinatal and Neonatal Medicine, Aichi Medical University, 1-1 Yazakokarimata, Nagakute, Aichi, 480-1195, Japan.
³ Department of Obstetrics and Gynecology, Aichi Medical University, 1-1 Yazakokarimata, Nagakute, Aichi, 480-1195, Japan.

PMID: 33403676
DOI: 10.1111/bjh.17294

No abstract available

Keywords: hypertensive disorders of pregnancy; romiplostim; small for gestational age infants; thrombocytopenia; thrombopoietin.

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Animals, Newborn
Birth Weight
Female
Hypertension / complications
Liver / metabolism
Liver / physiopathology*
Pregnancy
Pregnancy Complications, Cardiovascular / etiology
Rats
Rats, Wistar
Thrombocytopenia / etiology
Thrombocytopenia / metabolism
Thrombocytopenia / physiopathology*
Thrombopoietin / analysis
Thrombopoietin / metabolism*

Substances

Thrombopoietin

Grants and funding