In the present review, 182 antifouling (AF) natural products from marine microorganisms, algae and marine invertebrates reported from August 2014 to May 2020 are presented. Amongst these compounds, over half were isolated from marine-derived microorganisms, including 70 compounds from fungi and 31 compounds from bacteria. The structure-relationship of some of these compounds is also briefly discussed. Based on the work reported, a general workflow was drafted to refine the procedures for the commercialization of any novel AF compounds. Finally, butenolide, which is considered a potential environmentally friendly antifoulant, is used as a case study to show the procedures involved in AF compound work from the aspect of discovery, structure optimization, toxicity, stability, AF mechanism and coating incorporation, which highlight the current challenges and future perspectives in AF compound research.
Keywords: Antifouling; biofouling; butenolide; marine natural products.