The development of new technologies in medicine lead to creating an optimal treatment methods of cystic liver echinococcosis, based on minimally invasive technologies, such as percutaneous puncture-aspiration echinococcectomy (PAIR) under ultrasound (US) guidance. Aim of this study is to analyze and evaluate the efficiency of PAIR treatment. The study material included a retrospective analysis of 33 patients who underwent PAIR from December 2017 to December 2019. Of them, 25 (75%) patients with primary CLE, 8 (24%) patients with recurrent cystic liver echinococcosis. Cystic liver echinococcosis was staged according to WHO classification by US images. All patients pre- and postoperatively received therapy with Albendazole. The mean duration of surgery was 41 (30-70) min. Hospital stay times were ranged from 2 and 16 days (mean 4,8 days) in all patients. The conversion to laparotomy during the procedure was not necessary. Operation was finished in 3 cases due to developing anaphylactic shock during operation. There was no fatal outcome in any cases. One patient developed bilio-cystic communication, resolved spontaneously without additional treatment. The use of minimally invasive PAIR intervention followed by Albendazole therapy has a positive effect on reducing the patient's hospital stay.