Pyrazole-based analogs as potential antibacterial agents against methicillin-resistance staphylococcus aureus (MRSA) and its SAR elucidation

Rameshwari Verma; Santosh Kumar Verma; Kadalipura P Rakesh; Yarabahally R Girish; Milad Ashrafizadeh; Kothanahally S Sharath Kumar; Kanchugarakoppal S Rangappa

doi:10.1016/j.ejmech.2020.113134

Pyrazole-based analogs as potential antibacterial agents against methicillin-resistance staphylococcus aureus (MRSA) and its SAR elucidation

Eur J Med Chem. 2021 Feb 15:212:113134. doi: 10.1016/j.ejmech.2020.113134. Epub 2020 Dec 27.

Authors

Rameshwari Verma¹, Santosh Kumar Verma², Kadalipura P Rakesh³, Yarabahally R Girish⁴, Milad Ashrafizadeh⁵, Kothanahally S Sharath Kumar⁶, Kanchugarakoppal S Rangappa⁷

Affiliations

¹ School of Chemistry and Chemical Engineering, Yulin University, Yulin, 719000, Shaanxi, PR China; Shaanxi Key Laboratory of Low Metamorphic Coal Clean Utilization, Yulin University, Yulin, 719000, Shaanxi, PR China.
² School of Chemistry and Chemical Engineering, Yulin University, Yulin, 719000, Shaanxi, PR China; Shaanxi Key Laboratory of Low Metamorphic Coal Clean Utilization, Yulin University, Yulin, 719000, Shaanxi, PR China. Electronic address: vermasantosh08@yulinu.edu.cn.
³ School of Materials Science and Engineering, Wuhan Institute of Technology, Wuhan, 430073, PR China.
⁴ ACU-Centre for Research and Innovations, Faculty of Natural Sciences, Adichunchanagiri University, B.G. Nagara, Mandya, 571448, India.
⁵ Faculty of Engineering and Natural Sciences, Sabanci University, Orta Mahalle, Universite Caddesi No. 27, Orhanli, Tuzla, 34956, Istanbul, Turkey.
⁶ Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysuru, 570 006, India. Electronic address: sharu.shivaramu@gmail.com.
⁷ Institution of Excellence, University of Mysore, Vijnana Bhavan, Manasagangotri, Mysore, 570006, India. Electronic address: rangappaks@gmail.com.

PMID: 33395624
DOI: 10.1016/j.ejmech.2020.113134

Abstract

Methicillin-resistant Staphylococcus aureus (MRSA) is becoming lethal to humanity due to easy transmission and difficult-to-treat skin and flimsy diseases. The most threatening aspect is the rapid resistance development of MRSA to any approved antibiotics, including vancomycin. The development of new, efficient, and nontoxic drug candidate to fight against MRSA isolates is the need of the hour. The intriguing molecular structure and versatile bioactive pyrazole core attracting to development required novel antibiotics. This review presents the decade developments of pyrazole-containing derivatives with a broad antibacterial movement against diverged bacterial strains. In specific, we correlated the efficacy of structurally diversified pyrazole analogs against MRSA and discussed different angles of structure-activity relationship (SAR). The current survey highlights pyrazole hybrids' present scenario on MRSA studies, covering articles published from 2011 to 2020. This collective information may become an excellent platform to plan and develop new pyrazole-based small MRSA growth inhibitors with minimal side effects.

Keywords: Antibiotics; Drug discovery; MRSA; Pyrazole; SAR.

Publication types

Review

MeSH terms

Anti-Bacterial Agents / chemical synthesis
Anti-Bacterial Agents / chemistry
Anti-Bacterial Agents / pharmacology*
Dose-Response Relationship, Drug
Methicillin-Resistant Staphylococcus aureus / drug effects*
Microbial Sensitivity Tests
Molecular Structure
Pyrazoles / chemical synthesis
Pyrazoles / chemistry
Pyrazoles / pharmacology*
Structure-Activity Relationship

Substances

Anti-Bacterial Agents
Pyrazoles
pyrazole