Electrospinning and 3D bioprinting for intervertebral disc tissue engineering

Andrea De Pieri; Ann M Byerley; Catherine R Musumeci; Fatemeh Salemizadehparizi; Maya A Vanderhorst; Karin Wuertz-Kozak

doi:10.1002/jsp2.1117

Electrospinning and 3D bioprinting for intervertebral disc tissue engineering

JOR Spine. 2020 Aug 6;3(4):e1117. doi: 10.1002/jsp2.1117. eCollection 2020 Dec.

Authors

Andrea De Pieri¹, Ann M Byerley¹, Catherine R Musumeci¹, Fatemeh Salemizadehparizi¹, Maya A Vanderhorst¹, Karin Wuertz-Kozak^{1

2}

Affiliations

¹ Department of Biomedical Engineering Rochester Institute of Technology (RIT) Rochester New York USA.
² Schön Clinic Munich Harlaching, Spine Center Academic Teaching Hospital and Spine Research Institute of the Paracelsus Medical University Salzburg (AU) Munich Germany.

Abstract

Intervertebral disc (IVD) degeneration is a major cause of low back pain and represents a massive socioeconomic burden. Current conservative and surgical treatments fail to restore native tissue architecture and functionality. Tissue engineering strategies, especially those based on 3D bioprinting and electrospinning, have emerged as possible alternatives by producing cell-seeded scaffolds that replicate the structure of the IVD extracellular matrix. In this review, we provide an overview of recent advancements and limitations of 3D bioprinting and electrospinning for the treatment of IVD degeneration, focusing on future areas of research that may contribute to their clinical translation.

Keywords: MSCs; annulus fibrosus; bioink; biomaterials; endplate; extracellular matrix; nucleus pulposus; stem cells.

Publication types

Review