Assessment of Current Mental Health Status in a Population-Based Sample of Canadian Men With and Without a History of Prostate Cancer Diagnosis: An Analysis of the Canadian Longitudinal Study on Aging (CLSA)

Louise Moodie; Gabriela Ilie; Robert Rutledge; Pantelis Andreou; Susan Kirkland

doi:10.3389/fpsyt.2020.586260

Assessment of Current Mental Health Status in a Population-Based Sample of Canadian Men With and Without a History of Prostate Cancer Diagnosis: An Analysis of the Canadian Longitudinal Study on Aging (CLSA)

Front Psychiatry. 2020 Dec 16:11:586260. doi: 10.3389/fpsyt.2020.586260. eCollection 2020.

Authors

Louise Moodie¹, Gabriela Ilie^{1

2

3

4}, Robert Rutledge³, Pantelis Andreou¹, Susan Kirkland^{1

5}

Affiliations

¹ Department of Community Health and Epidemiology, Dalhousie University, Halifax Regional Municipality, NS, Canada.
² Department of Urology, Dalhousie University, Halifax Regional Municipality, NS, Canada.
³ Department of Radiation Oncology, Dalhousie University, Halifax Regional Municipality, NS, Canada.
⁴ Department of Psychology and Neuroscience, Dalhousie University, Halifax Regional Municipality, NS, Canada.
⁵ Geriatric Medicine, Department of Medicine, Dalhousie University, Halifax Regional Municipality, NS, Canada.

Abstract

Background: Small-scale studies indicate an increase in mental health disorders among prostate cancer survivors compared to the general population, but large population-based data assessing this relationship are scarce. The present study examined the prevalence of lifetime history of prostate cancer in a cross-sectional sample of Canadian men and assessed the contribution of lifetime history of a prostate cancer diagnosis, multimorbidity, and current alcohol and smoking status to the association with current mental health outcomes in this population. Methods: The analytical sample included 25,183 men (aged 45 to 85 years old), who completed a survey as part of the Canadian Longitudinal Study on Aging (CLSA). The Center for Epidemiological Studies Depression Scale (CES-D10), Kessler's Psychological Distress Scale (K10), and self-reported mental health were mental health outcomes. Multiple logistic regression analyses, and controlling for the complexity of the design and covariates, evaluated the association between prostate cancer survivorship, multimorbidity, alcohol and smoking status, and current mental health outcomes. Results: The prevalence of lifetime history of prostate cancer diagnosis in this population-based sample of men was 4% (95% CI: 3.7, 4.4). Our results indicate statistically significantly higher odds of current psychological distress (aOR = 1.52, 95% CI: 1.09, 2.11) and screening positive for depression (aOR = 1.24; 95% CI: 1.02, 1.51) among survivors of prostate cancer, compared to men without a history of prostate cancer diagnosis in demographics controlled analyses. After addition of multimorbidity and substance use, the odds of screening positive for depression among survivors of prostate cancer are 1.32 (95% CI: 1.06, 1.64) higher compared to men who never had a history of prostate cancer diagnosis. Interpretation: Patient education and empowerment programs aimed at addressing concerns during the diagnosis and treatment and enhancing survivorship care plans by adding routine screening for mental distress to help survivors overcome poor mental health during the cancer survivorship journey, are warranted.

Keywords: anxiety; cancer survivorship; depression; mental health; multimorbidity; prostate cancer; quality of life; substance use.