In the jubilee paper devoted to Professor Shu-Ting Chang, we aimed to outline the applicability of the Le Chatelier principle to various fields, especially to cancer biology and immunotherapy of malignant neoplasms. Cancer progression has been shown to be associated with a response to cell stress and survival agents. It was proclaimed that cancer immunotherapy, using fungal metabolites, should be carried out as a mode of compensation for imbalances that arise during the basic treatment. The challenges of immunotherapy in recent years have also received mention.