Abstract
The AAA-ATPase p97/Cdc48 is one of the most abundant proteins in eukaryotes, and owing to its multiple functions, is considered the swiss army knife of cells. Recent findings demonstrate that p97/Cdc48 and its cofactor p47/Shp1 control the heavy metal stress response by active, signal-triggered disassembly of a multisubunit ubiquitin ligase. Here we review this pathway and describe recently achieved mechanistic insight into the role of p47/Shp1 in this process.
Keywords:
Cadmium response; Cdc48/p97; SCF ubiquitin ligase; Shp1/p47.
MeSH terms
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Adenosine Triphosphate / genetics
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Cell Cycle Proteins / genetics
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Intracellular Signaling Peptides and Proteins / genetics*
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Multiprotein Complexes / genetics*
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Multiprotein Complexes / ultrastructure
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Proteasome Endopeptidase Complex / genetics*
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Proteasome Endopeptidase Complex / ultrastructure
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Protein Binding / genetics
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Saccharomyces cerevisiae / genetics
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Saccharomyces cerevisiae Proteins / genetics*
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Saccharomyces cerevisiae Proteins / ultrastructure
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Ubiquitin / genetics
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Valosin Containing Protein / genetics*
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Valosin Containing Protein / ultrastructure
Substances
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Cell Cycle Proteins
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Intracellular Signaling Peptides and Proteins
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Multiprotein Complexes
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SHP1 protein, S cerevisiae
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Saccharomyces cerevisiae Proteins
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Ubiquitin
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Adenosine Triphosphate
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Proteasome Endopeptidase Complex
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CDC48 protein, S cerevisiae
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Valosin Containing Protein