TGF-β signaling and microRNA cross-talk regulates abdominal aortic aneurysm progression

Ying Tang; Wenjing Fan; Bu Zou; Wei Yan; Yangfeng Hou; Oware Kwabena Agyare; Zhisheng Jiang; Shunlin Qu

doi:10.1016/j.cca.2020.12.031

TGF-β signaling and microRNA cross-talk regulates abdominal aortic aneurysm progression

Clin Chim Acta. 2021 Apr:515:90-95. doi: 10.1016/j.cca.2020.12.031. Epub 2020 Dec 31.

Authors

Ying Tang¹, Wenjing Fan², Bu Zou¹, Wei Yan¹, Yangfeng Hou¹, Oware Kwabena Agyare³, Zhisheng Jiang⁴, Shunlin Qu⁵

Affiliations

¹ Pathophysiology Department, Institute of Cardiovascular Disease, Key Laboratory for Arteriosclerology of Hunan Province, Hunan International Scientific and Technological Cooperation Base of Arteriosclerotic Disease, University of South China, Hengyang, Hunan 421001, PR China; Clinic Department, Hengyang Medical College, University of South China, Hengyang 421001, PR China.
² Pathophysiology Department, Institute of Cardiovascular Disease, Key Laboratory for Arteriosclerology of Hunan Province, Hunan International Scientific and Technological Cooperation Base of Arteriosclerotic Disease, University of South China, Hengyang, Hunan 421001, PR China; Emergency Department, The Second Affiliated Hospital, University of South China, Hengyang City, Hunan Province 421001, PR China.
³ International College, Hengyang Medical School, University of South China, Hengyang City, Hunan Province 421001, PR China.
⁴ Pathophysiology Department, Institute of Cardiovascular Disease, Key Laboratory for Arteriosclerology of Hunan Province, Hunan International Scientific and Technological Cooperation Base of Arteriosclerotic Disease, University of South China, Hengyang, Hunan 421001, PR China.
⁵ Pathophysiology Department, Institute of Cardiovascular Disease, Key Laboratory for Arteriosclerology of Hunan Province, Hunan International Scientific and Technological Cooperation Base of Arteriosclerotic Disease, University of South China, Hengyang, Hunan 421001, PR China. Electronic address: qushunlin78@126.com.

PMID: 33388307
DOI: 10.1016/j.cca.2020.12.031

Abstract

Abdominal aortic aneurysms (AAA) are permanent and irreversible local dilatations of the abdominal aortic wall. Recent data indicate that the transforming growth factor-beta (TGF-β) signaling pathway exerts a protective effect on the development of AAA. Some dysregulated microRNAs (miRNA) also appear involved in the expansion of AAA and miRNA-based therapeutics have been shown to effectively inhibit this process. New evidence has revealed that TGF-β signaling and miRNA interaction may of physiologic and pathophysiologic significance including the progression of AAA. As such, miRNA that regulate TGF-β signaling may hold promise as potential therapeutic targets. This review explores potential crosstalk between TGF-β signaling and miRNA in AAA in order improve our understanding of this pathology and explore development of potential therapeutic targets.

Keywords: Abdominal aortic aneurysms; MicroRNA; TGF-β signaling pathway.

Publication types

Review

MeSH terms

Aortic Aneurysm, Abdominal* / genetics
Humans
MicroRNAs* / genetics
Signal Transduction
Transforming Growth Factor beta

Substances

MicroRNAs
Transforming Growth Factor beta