AFP-producing Xp11 translocation renal cell carcinoma: Case report and review of the literature

Hui-Zhi Zhang; Su-Ying Wang

doi:10.1016/j.currproblcancer.2020.100689

AFP-producing Xp11 translocation renal cell carcinoma: Case report and review of the literature

Curr Probl Cancer. 2021 Jun;45(3):100689. doi: 10.1016/j.currproblcancer.2020.100689. Epub 2020 Dec 29.

Authors

Hui-Zhi Zhang¹, Su-Ying Wang²

Affiliations

¹ Department of Pathology, Ningbo Diagnostic Pathology Center, Ningbo, Zhejiang, China.
² Department of Pathology, Ningbo Diagnostic Pathology Center, Ningbo, Zhejiang, China. Electronic address: suying15058889252@163.com.

PMID: 33388149
DOI: 10.1016/j.currproblcancer.2020.100689

Abstract

Alpha-fetoprotein (AFP) is a useful tumor marker for hepatocellular carcinomas and yolk sac tumors. Rare extrahepatic visceral malignancies may be associated with AFP production and those exhibiting a hepatoid differentiation by morphology and immunohistochemical are classified as hepatoid adenocarcinoma. Renal cell carcinoma (RCC) producing AFP is a rare entity. To date, only one case of AFP-producing Xp11 translocation RCC has been reported. We reported another case of Xp11 translocation RCC, in which the tumor cells displayed strong immunostaining for AFP, HepPar1, and GPC-3. Additionally, the other published cases are reviewed.

Keywords: AFP; Renal cell carcinoma; TFE3.

Publication types

Case Reports
Review

MeSH terms

Adult
Biomarkers, Tumor
Carcinoma, Renal Cell / blood*
Carcinoma, Renal Cell / pathology
Carcinoma, Renal Cell / surgery
Humans
Kidney Neoplasms / blood*
Kidney Neoplasms / pathology
Kidney Neoplasms / surgery
Male
Translocation, Genetic
Treatment Outcome
alpha-Fetoproteins / analysis*

Substances

AFP protein, human
Biomarkers, Tumor
alpha-Fetoproteins