STIM2: Redox-sensor and effector of the (tumor) microenvironment

Abstract

Ion channels and their associated proteins are at the interface between the cytosol and the extracellular space. In cancer, this allows them to sense and transduce physico-chemical cues from the tumor microenvironment and thereby shape the aggressive cell behavior. In a recent paper Gibhardt et al. provide profound mechanistic insight how STIM2, an integral component of the store-operated Ca²⁺ entry (SOCE) mechanism in melanoma cells, is redox-regulated.

Keywords: Redox regulation; STIM2; Store-operated Ca(2+) entry (SOCE); Tumor microenvironment.