Reduced H3 histamine receptor binding densities in the upper layers of motor cortex in rats prone to audiogenic convulsive seizures

I S Midzyanovskaya; T E Petrenko; L M Birioukova; L M Tuomisto

doi:10.1016/j.eplepsyres.2020.106543

Reduced H3 histamine receptor binding densities in the upper layers of motor cortex in rats prone to audiogenic convulsive seizures

Epilepsy Res. 2021 Feb:170:106543. doi: 10.1016/j.eplepsyres.2020.106543. Epub 2020 Dec 25.

Authors

I S Midzyanovskaya¹, T E Petrenko², L M Birioukova³, L M Tuomisto⁴

Affiliations

¹ Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Russian Federation; University of Eastern Finland, School of Pharmacy, Finland. Electronic address: miinn@yandex.ru.
² Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Russian Federation; Pirogov Russian National Research Medical University, Russian Federation.
³ Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Russian Federation; University of Eastern Finland, School of Pharmacy, Finland.
⁴ University of Eastern Finland, School of Pharmacy, Finland.

PMID: 33387800
DOI: 10.1016/j.eplepsyres.2020.106543

Abstract

Fits of audiogenic seizures in rodents are considered as a model for generalized convulsive epilepsies in humans. The laminar distribution of the H3 histamine receptor binding densities was quantified in the motor cortex of two strains of rats with genetically determined generalized epilepsies, namely KM rats with audiogenic seizures only, and WAGRij rats with both audiogenic seizures and absence seizures. It was found that H3 histamine receptor binding densities in layer 2/3d of the primary and secondary motor cortices of the rats that experienced audiogenic seizure fits were significantly lower than in the cortices of control rats. Possible explanations are discussed.

Keywords: Animal model; Audiogenic seizure fits; Generalized epilepsy; H3 histamine receptor; Motor cortex.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Acoustic Stimulation
Animals
Epilepsy, Generalized*
Epilepsy, Reflex*
Motor Cortex*
Rats
Rats, Wistar
Receptors, Histamine
Seizures

Substances

Receptors, Histamine