1 Department of Critical Care Medicine, Queen's University, Kingston, ON, Canada. david.maslove@queensu.ca.
2 Kingston Health Sciences Centre, Kingston, ON, Canada. david.maslove@queensu.ca.
3 Department of Intensive Care Medicine and Research VUmc Intensive Care (REVIVE), VU University Medical Center Amsterdam, Amsterdam, The Netherlands.
4 Institute for Cardiovascular Research VU (ICaR-VU), VU University Medical Center Amsterdam, Amsterdam, The Netherlands.
5 The Clinical Research, Investigation, and Systems Modeling of Acute Illness (CRISMA) Center, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.