Optimisation and application of an analytical approach for the characterisation of TiO2 nanoparticles in food additives and pharmaceuticals by single particle inductively coupled plasma-mass spectrometry

Abstract

This study was designed to optimise an analytical method for characterising TiO₂ nanoparticles (NPs) in food additives and pharmaceuticals by inductively coupled plasma-mass spectrometry in single particle mode (spICP-MS). Several parameters, including transport efficiency (TE), were assessed and optimised using the NM-100 reference material. We found that self-aspiration for sample intake and use of the concentration-based method for TE was optimal for characterising TiO₂ NPs. No spectral interference was observed with either ⁴⁹Ti or ⁴⁸Ti isotopes. The optimised Excel spreadsheet developed for this study not only provided additional parameters but gave results closer to the NM-100 reference value than the ICP-MS software. The method was then applied to the analysis of a selection of food samples and pharmaceuticals. The average diameter of TiO₂ particles ranged from 86 to 179 nm in the food samples and from 131 to 197 nm in the pharmaceuticals, while the nanoparticular fraction was between 19 and 68% in food, and between 13 and 45% in pharmaceuticals.

Keywords: Data processing; E171; Food & pharmaceutical; Threshold; TiO(2) nanoparticle; spICP-MS.