Regulatory mechanisms and clinical significance of vimentin in breast cancer

Zhilong Chen; Zheng Fang; Ji Ma

doi:10.1016/j.biopha.2020.111068

Regulatory mechanisms and clinical significance of vimentin in breast cancer

Biomed Pharmacother. 2021 Jan:133:111068. doi: 10.1016/j.biopha.2020.111068. Epub 2020 Dec 8.

Authors

Zhilong Chen¹, Zheng Fang¹, Ji Ma²

Affiliations

¹ Department of Medical Oncology, West China Hospital, Sichuan University, Chengdu, Sichuan Province, 610041, PR China; West China College of Stomatology, Sichuan University, Chengdu, Sichuan Province, 610041, PR China.
² Department of Medical Oncology, West China Hospital, Sichuan University, Chengdu, Sichuan Province, 610041, PR China. Electronic address: majimrn@163.com.

PMID: 33378968
DOI: 10.1016/j.biopha.2020.111068

Abstract

Vimentin, a kind of intermediate filament protein III in mesenchymal cells, has become a highly researched topic around the world in recent years, as it holds complex biological functions and plays an important role in the epithelial-mesenchymal transition in the evolution of various tumors. This article reviews the biological function of vimentin and its relationship with breast cancer in order to provide novel ideas about the clinical diagnosis and targeted therapy of breast cancer.

Keywords: Biological function; Breast cancer; Clinical significance; Regulatory mechanism; Vimentin.

Publication types

Review

MeSH terms

Animals
Biomarkers, Tumor / genetics
Biomarkers, Tumor / metabolism*
Breast Neoplasms / genetics
Breast Neoplasms / metabolism*
Breast Neoplasms / pathology
Breast Neoplasms / therapy
Female
Gene Expression Regulation, Neoplastic
Humans
Prognosis
Signal Transduction
Vimentin / genetics
Vimentin / metabolism*

Substances

Biomarkers, Tumor
VIM protein, human
Vimentin