Extended SEIQR type model for COVID-19 epidemic and data analysis

Math Biosci Eng. 2020 Nov 2;17(6):7562-7604. doi: 10.3934/mbe.2020386.

Abstract

An extended SEIQR type model is considered in order to model the COVID-19 epidemic. It contains the classes of susceptible individuals, exposed, infected symptomatic and asymptomatic, quarantined, hospitalized and recovered. The basic reproduction number and the final size of epidemic are determined. The model is used to fit available data for some European countries. A more detailed model with two different subclasses of susceptible individuals is introduced in order to study the influence of social interaction on the disease progression. The coefficient of social interaction K characterizes the level of social contacts in comparison with complete lockdown (K=0) and the absence of lockdown (K=1). The fitting of data shows that the actual level of this coefficient in some European countries is about 0.1, characterizing a slow disease progression. A slight increase of this value in the autumn can lead to a strong epidemic burst.

Keywords: COVID-19; relapse; reproduction number; two group model.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Basic Reproduction Number
  • COVID-19 / epidemiology*
  • Communicable Disease Control
  • Data Analysis*
  • Disease Progression
  • Disease Susceptibility
  • Disease-Free Survival
  • Epidemics
  • Epidemiological Monitoring*
  • Europe / epidemiology
  • Hospitalization
  • Humans
  • Models, Theoretical
  • Quarantine
  • Recurrence
  • Social Behavior