Oral lichen planus (OLP) is a common chronic inflammatory disease of the oral mucosa. The prevalence rate of OLP in adults is 0.5%-2%. The etiology and pathogenesis of OLP are still unclear. The pathogenesis of OLP may be related to the genetic polymorphism of some genes. Currently, the gene families, including tumor necrosis factor, interferon, interleukin, enzyme, and receptor, have been extensively studied. This work reviews related studies on gene polymorphism of OLP.
口腔扁平苔藓（OLP）是一种常见的口腔黏膜慢性炎症性疾病，成年人患病率为0.5%~2%。OLP的病因和发病机制尚不明确，研究显示其发病可能与某些基因的遗传多态性相关，目前研究较多的有肿瘤坏死因子、干扰素、白细胞介素、酶类、受体等基因家族。本文就基因多态性与口腔扁平苔藓的相关性进行综述。.
Keywords: etiology; gene polymorphism; genetics; oral lichen planus.