Higher Serum-Soluble α-Klotho Level Does Not Predict Longer Survival after Stroke

Biomed Res Int. 2020 Dec 7:2020:9283651. doi: 10.1155/2020/9283651. eCollection 2020.

Abstract

Results: There were 5 recurrent strokes and 89 deaths during the 36-month follow-up. Even though no significant differences in OS and SFS between soluble α-Klotho level tertile groups were recorded, unexpectedly, OS and SFS were highest in patients with the lowest soluble α-Klotho concentrations. Moreover, the Cox proportional models adjusted for established risk factors, kidney function, and the severity of stroke revealed that each 100 pg/mL increase in soluble α-Klotho levels was associated with decreased OS (HR = 0.951 (0.908-0.995), p < 0.05) and SFS (HR = 0.949 (0.908-0.993), p < 0.05). In addition, the α-Klotho to iFGF23 index was predicting neither OS nor SFS.

Conclusion: Soluble α-Klotho levels in serum were not related to the severity of neurological deficits and long-term outcomes in patients with IS. No neuroprotective effect of soluble α-Klotho levels in patients with IS was demonstrated.

MeSH terms

  • Aged
  • Aged, 80 and over
  • Biomarkers / blood
  • Female
  • Fibroblast Growth Factors / blood
  • Follow-Up Studies
  • Glomerular Filtration Rate
  • Glucuronidase / blood*
  • Humans
  • Klotho Proteins
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Proportional Hazards Models
  • Prospective Studies
  • Recurrence
  • Renal Insufficiency, Chronic / blood
  • Risk Factors
  • Stroke / diagnostic imaging
  • Stroke / mortality*
  • Stroke / physiopathology*
  • Tomography, X-Ray Computed
  • Treatment Outcome

Substances

  • Biomarkers
  • Fibroblast Growth Factors
  • Glucuronidase
  • Klotho Proteins