Trends and recent development of the microelectrode arrays (MEAs)

Longqian Xu; Chenxuan Hu; Qi Huang; Kai Jin; Ping Zhao; Dongping Wang; Wei Hou; Lihua Dong; Siyi Hu; Hanbin Ma

doi:10.1016/j.bios.2020.112854

Trends and recent development of the microelectrode arrays (MEAs)

Biosens Bioelectron. 2021 Mar 1:175:112854. doi: 10.1016/j.bios.2020.112854. Epub 2020 Nov 26.

Authors

Longqian Xu¹, Chenxuan Hu¹, Qi Huang¹, Kai Jin², Ping Zhao², Dongping Wang¹, Wei Hou³, Lihua Dong³, Siyi Hu¹, Hanbin Ma⁴

Affiliations

¹ CAS Key Laboratory of Bio-medical Diagnostics, Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, No.88 Keling Road, Suzhou, Jiangsu province, 215163, PR China.
² CAS Key Laboratory of Bio-medical Diagnostics, Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, No.88 Keling Road, Suzhou, Jiangsu province, 215163, PR China; International Joint Research Center for Nanophotonics and Biophotonics, School of Science, Changchun University of Science and Technology, Changchun, Jilin province, 130022, PR China.
³ Department of Radiation Oncology & Therapy, The First Hospital of Jilin University, NO.1 Xinmin Street, Changchun, Jilin province, 130021, PR China.
⁴ CAS Key Laboratory of Bio-medical Diagnostics, Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, No.88 Keling Road, Suzhou, Jiangsu province, 215163, PR China. Electronic address: mahb@sibet.ac.cn.

PMID: 33371989
DOI: 10.1016/j.bios.2020.112854

Abstract

In this paper, we reviewed the history of microelectrode arrays (MEAs), compared different microfabrication techniques applied to modern MEAs in terms of their material characters, device properties and application scenarios. Then we discussed the biocompatibility of different MEAs as well as corresponding strategy of improvement. At last, we analyzed the growing trend of MEAs' technical route, expected application of MEAs in the field of Electrical impedance tomography (EIT).

Keywords: EIT; Flexible electronics; In vitro; In vivo; MEAs.

Publication types

Review

MeSH terms

Biosensing Techniques*
Microelectrodes
Microtechnology