Objective: To investigate the clinical effect of ipsilateral simultaneous pancreas and kidney transplantation (SPK). Methods: A total of 146 cases of SPK surgeries completed in the Second Affiliated Hospital of Guangzhou Medical University from September 2016 to June 2020 were selected to summarize the outcome, curative effect and complications of the operation. Results: The patients were followed up for 1 to 45 months. Good clinical results were obtained in 146 patients. Renal function indicators suggest that on the 7th day after operation, the serum creatinine returned to normal level [142.4 (108.6, 213.4)μmol/L]. The index of pancreatic function decreased to the normal level as expected. The level of blood amylase was 160.5(109.3, 249.8) U/L within 7 days after operation, and then decreased. The trend of urinary amylase was similar to that of blood amylase, which was 240(121.0, 370.0) U/L 7 days after operation, and glycosylated hemoglobin decreased to the normal level (5.8%±1.4%) 1 month after operation. The main medical complications were infection including pulmonary infection (26.03%, 38/146), urinary tract infection (26.03%,38/146), and abdominal infection (4.79%,7/146), acute rejection including renal graft rejection (5.8%,8/146), pancreas/duodenum rejection (18.49%,27/146), and renal graft combined pancreatic graft rejeciton (6.85%,10/146), as well as gastrointestinal bleeding (30.82%,45/146), of which 5 cases were severe bleeding (3.42%, 5/146). The main surgical complications were poor incision healing (10.27%, 15/146), serious surgical complications including arteriovenous thrombosis of the transplanted pancreas (2.05%, 3/146) and intestinal leakage (0.68%,1/146). The 1-year and 3-year patient, renal and pancreatic survival rates were both 92.5%, 91.5% and 89.5%, respectively, and despite the death, the 1-year, 3-year transplanted kidney survival rate was both 99.3%, and 95% for the the 1-year, 3-year pancreas survival rate. Conclusion: Strict preoperative evaluation of the function of large organs, reasonable surgical methods, perioperative anticoagulation, and prompt diagnosis of complications can achieve good clinical results for patients with SPK.
目的： 探讨同侧胰肾联合移植术的临床效果和安全性。 方法： 选择2016年9月至2020年6月广州医科大学附属第二医院器官移植中心完成的146例胰肾联合移植手术受者作为对象，总结同侧胰肾联合移植手术方式受者的结局、疗效及并发症。 结果： 受者随访1~45个月，取得良好的临床效果。肾功能指标提示，血清肌酐在术后第7天恢复至142.4（108.6，213.4）μmol/L。胰腺功能指标如期下降至参考范围。血淀粉酶在术后7 d内偏高，为160.5（109.3，249.8）U/L，随后下降，尿淀粉酶趋势与血淀粉酶相似，术后第7天为240（121.0，370.0）U/L；糖化血红蛋白术后1个月下降至参考范围内，为5.8%±1.4%，主要内科并发症为感染[肺部感染26.03%（38/146），泌尿系感染26.03%（38/146），腹腔感染4.79%（7/146）]、急性排斥反应[移植肾急性排斥反应5.8%（8/146），移植胰/十二指肠急性排斥反应18.49%（27/146），移植肾合并移植胰急性排斥反应6.85%（10/146）]、消化道出血30.82%（45/146），其中严重出血3.42%（5/146）。主要外科并发症为切口愈合不良，占10.27%（15/146），严重的外科并发症为移植胰动静脉血栓形成，占2.05%（3/146），肠漏占0.68%（1/146）。1、3年人、肾、胰腺生存率均分别为92.5%、91.5%、89.0%，死亡删除的移植肾1、3年生存率为均为99.3%，死亡删除的胰腺1、3年生存率均为95.0%。 结论： 严格供受者器官功能的评估，积极预防、诊断和处理内外科并发症，同侧胰肾联合移植的术式具有手术操作更简单、并发症发生率更低等优势，可取得良好的临床效果。.
Keywords: Complications; Kidney transplantation; Pancreas transplantation; Pancreatic function; Renal function.