Cobalt Bis(dicarbollide) Alkylsulfonamides: Potent and Highly Selective Inhibitors of Tumor Specific Carbonic Anhydrase IX

Bohumír Grüner; Michael Kugler; Suzan El Anwar; Josef Holub; Jan Nekvinda; Dmytro Bavol; Zdeňka Růžičková; Klára Pospíšilová; Milan Fábry; Vlastimil Král; Jiří Brynda; Pavlína Řezáčová

doi:10.1002/cplu.202000717

Cobalt Bis(dicarbollide) Alkylsulfonamides: Potent and Highly Selective Inhibitors of Tumor Specific Carbonic Anhydrase IX

Chempluschem. 2021 Mar;86(3):351. doi: 10.1002/cplu.202000717. Epub 2020 Dec 28.

Affiliations

¹ Department of Synthesis, Institute of Inorganic Chemistry of the Czech Academy of Sciences, 250 68, Řež, Czech Republic.
² Institute of Molecular Genetics of the Czech Academy of Sciences, Vídeňská 1083, 142 20, Prague 4, Czech Republic.
³ Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Flemingovo nám. 2, 166 10, Prague, Czech Republic.
⁴ Department of General and Inorganic Chemistry, Faculty of Chemical Technology, University of Pardubice, Studentská 573, 532 10, Pardubice, Czech Republic.

PMID: 33369232
DOI: 10.1002/cplu.202000717

Abstract

Invited for this month's cover is a collaboration from three institutes from the Czech Academy of Sciences: Institute of Inorganic Chemistry, Institute of Organic Chemistry and Biochemistry, and Institute of Molecular Genetics, and the University of Pardubice. The cover picture shows a family of potent and selective CA IX inhibitors that combines the structural motif of a bulky inorganic cobalt bis(dicarbollide) polyhedral ion with a propylsulfonamido anchor group. Read the full text of the article at 10.1002/cplu.202000574.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Carbonic Anhydrase IX
Carbonic Anhydrase Inhibitors*
Cobalt
Humans
Neoplasms*

Substances

Carbonic Anhydrase Inhibitors
Cobalt
Carbonic Anhydrase IX