Clinical Aggressiveness of TP53-Wild Type Sonic Hedgehog Medulloblastoma With MYCN Amplification, Chromosome 17p Loss, and Chromothripsis

J Neuropathol Exp Neurol. 2021 Jan 20;80(2):205-207. doi: 10.1093/jnen/nlaa124.
No abstract available

Publication types

  • Case Reports
  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cerebellar Neoplasms / diagnostic imaging
  • Cerebellar Neoplasms / genetics
  • Cerebellar Neoplasms / pathology*
  • Child
  • Chromothripsis*
  • Disease Progression
  • Fatal Outcome
  • Gene Amplification*
  • Hedgehog Proteins / genetics*
  • Humans
  • Male
  • Medulloblastoma / diagnostic imaging
  • Medulloblastoma / genetics
  • Medulloblastoma / pathology*
  • Mutation
  • N-Myc Proto-Oncogene Protein / genetics*
  • Tumor Suppressor Protein p53 / genetics*

Substances

  • Hedgehog Proteins
  • N-Myc Proto-Oncogene Protein
  • Tumor Suppressor Protein p53