A case report of a drug-induced liver injury (DILI) caused by multiple antidepressants with causality established by the updated Roussel Uclaf causality assessment method (RUCAM) and in vitro testing

Miguel González-Muñoz; Jaime Monserrat Villatoro; Eva Marín-Serrano; Stefan Stewart; Belén Bardón Rivera; Jesús Marín; Lucía Martínez de Soto; Enrique Seco Meseguer; Elena Ramírez

doi:10.1002/ccr3.3348

A case report of a drug-induced liver injury (DILI) caused by multiple antidepressants with causality established by the updated Roussel Uclaf causality assessment method (RUCAM) and in vitro testing

Clin Case Rep. 2020 Sep 21;8(12):3105-3109. doi: 10.1002/ccr3.3348. eCollection 2020 Dec.

Authors

Miguel González-Muñoz¹, Jaime Monserrat Villatoro², Eva Marín-Serrano³, Stefan Stewart², Belén Bardón Rivera⁴, Jesús Marín⁴, Lucía Martínez de Soto², Enrique Seco Meseguer², Elena Ramírez²

Affiliations

¹ Immunology Department La Paz-Cantoblanco-Carlos III University Hospital IdiPaz Madrid España.
² Clinical Pharmacology Department Facultad de Medicina La Paz-Cantoblanco-Carlos III University Hospital IdiPaz Universidad Autónoma de Madrid Madrid España.
³ Gastroenterology and Hepatology Department La Paz-Cantoblanco-Carlos III University Hospital IdiPaz Madrid España.
⁴ Psiquiatry Department La Paz-Cantoblanco-Carlos III University Hospital, IdiPaz Madrid España.

Abstract

A 56-year-old female patient was hospitalized because of a lack of response and poor tolerance to multiple antidepressants, which included an episode of DILI. During hospitalization, the patient suffered another episode of DILI. Causality was assessed both by RUCAM and Lymphocyte Transformation Test, allowing to identify a safer medication.

Keywords: Roussel Uclaf Causality Assessment Method (RUCAM); antidepressants; causality assessment; drug‐induced liver injury (DILI); lymphocyte transformation test (LTT); pharmacovigilance.

Publication types

Case Reports