Monochorionic twins discordant for trisomy 13: A case report, systematic literature search and synthesis of available evidence

Emily F Cornish; Ruwan Wimalasundera; George Attilakos

doi:10.1002/ccr3.3244

Monochorionic twins discordant for trisomy 13: A case report, systematic literature search and synthesis of available evidence

Clin Case Rep. 2020 Sep 1;8(12):2798-2802. doi: 10.1002/ccr3.3244. eCollection 2020 Dec.

Authors

Emily F Cornish¹, Ruwan Wimalasundera², George Attilakos²

Affiliations

¹ UCL Elizabeth Garrett Anderson Institute for Women's Health University College London (UCL) London UK.
² Fetal Medicine Unit University College London Hospitals London UK.

Abstract

This article presents the tenth reported case of monochorionic twins discordant for trisomy 13. Discordant aneuploidies in monochorionic twins are rare. Aetiologies include mitotic error in early cell division and "rescue" chromosome loss in an initially trisomic zygote. Clinicians should offer early amniocentesis of both sacs and consider selective termination.

Keywords: amniocentesis; discordant anomalies; monochorionic twins; selective termination; trisomy 13.

Publication types

Case Reports