Rare Case of Late-Onset Narcolepsy Type 1

Petra Kovalská; Simona Dostálová; Hana Machová; Petra Nytrová; Eszter Maurovich Horvat; Karel Šonka

doi:10.1159/000510633

Rare Case of Late-Onset Narcolepsy Type 1

Case Rep Neurol. 2020 Nov 12;12(3):428-432. doi: 10.1159/000510633. eCollection 2020 Sep-Dec.

Authors

Petra Kovalská¹, Simona Dostálová¹, Hana Machová², Petra Nytrová¹, Eszter Maurovich Horvat¹, Karel Šonka¹

Affiliations

¹ Department of Neurology and Centre of Clinical Neuroscience, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czechia.
² Inspamed, Ltd., Institute of Sleep Medicine, Prague, Czechia.

Abstract

A 69-year-old male developed symptoms typical of the diagnosis of narcolepsy type 1 without any previous triggering events. First, daytime sleepiness occurred, soon followed by cataplexy. Nocturnal polysomnography revealed rapid eye movement (REM) sleep behavior disorder, a apnea-hypopnea index of 25.8 events/h, and no sleep-onset REM. Multiple Sleep Latency Test showed a mean sleep latency of 2.1 min and REM sleep in 3 tests. HLA DQB1*06:02 was positive and hypocretin-1 in cerebrospinal fluid unmeasurable. A treatment with 50 mg clomipramine controlled the cataplexy; excessive daytime sleepiness was sufficiently managed by repeated naps. The administration of 0.25 mg of clonazepam subjectively improved REM sleep behavior disorder. Bilevel Positive Airway Pressure improved the apnea-hypopnea index without important influence on sleepiness. Our unique case demonstrates that even elderly subjects can develop narcolepsy type 1.

Keywords: Elderly; Narcolepsy with cataplexy; Rare case.

Publication types

Case Reports