RADIATION DAMAGE OF THE NERVOUS SYSTEM AND ENDOCANABINOIDS

Probl Radiac Med Radiobiol. 2020 Dec:25:75-89. doi: 10.33145/2304-8336-2020-25-75-89.
[Article in English, Ukrainian]

Abstract
in English, Ukrainian

The review analyzes the change of the existing paradigm of high radioresistance of the nervous system according tothe results of the study of neuropsychiatric disorders in in the aftermath of the Chornobyl accident in both earlyand remote post-accident period. The participation of the endocannabinoid system in ensuring homeostasis andpathology formation, potential possibilities of using cannabis drugs, agonists and antagonists of endocannabinoidreceptors for the treatment of early and long-term effects of radiation are considered.

V ogliadi proanalizovano zminu isnuiuchoï paradygmy pro vysoku radiorezystentnist' nervovoï systemy za rezul'tatamy doslidzhennia neĭropsykhiatrychnykh rozladiv v uchasnykiv likvidatsiï naslidkiv avariï na Chornobyl's'kiĭ AESiak v rann'omu, tak i u viddalenomu pisliaavariĭnomu periodi. Rozglianuto uchast' endokanabinoïdnoï systemy v zabezpechenni gomeostazu i formuvanni patologiï, potentsiĭni mozhlyvosti zastosuvannia preparativ kanabisu,agonistiv i antagonistiv endokanabinoïdnykh retseptoriv dlia likuvannia rannikh i viddalenykh naslidkiv oprominennia.

Keywords: endocannabinoid system; ionizing radiation; nervous system.

Publication types

  • Review

MeSH terms

  • Chernobyl Nuclear Accident*
  • Dose-Response Relationship, Radiation
  • Endocannabinoids / metabolism
  • Endocannabinoids / therapeutic use*
  • Fatigue Syndrome, Chronic / etiology
  • Fatigue Syndrome, Chronic / metabolism
  • Fatigue Syndrome, Chronic / pathology*
  • Fatigue Syndrome, Chronic / therapy
  • Humans
  • Mental Disorders / etiology
  • Mental Disorders / metabolism
  • Mental Disorders / pathology*
  • Mental Disorders / therapy
  • Nervous System / pathology
  • Nervous System / radiation effects
  • Neurons / pathology
  • Neurons / radiation effects
  • Radiation Dosage
  • Radiation Exposure / adverse effects*
  • Radiation Injuries / etiology
  • Radiation Injuries / metabolism
  • Radiation Injuries / pathology*
  • Radiation Injuries / therapy
  • Radiation, Ionizing
  • Receptors, Cannabinoid / metabolism
  • Time Factors

Substances

  • Endocannabinoids
  • Receptors, Cannabinoid